61/2018: PN-III-P1-1.1-PD-2016-0605

 

Project summary

 

As bacteria adapt quickly, current antibiotics become ineffective, leading the era of antibiotics to a close end. Patients in critical care units and those with indwelling devices are the most prone to severe infections, caused by resistant and biofilm related pathogens, which cause more than 70% of the deaths in these patients. Utilizing high amounts of antibiotics impose severe adverse effects against the patient (all antibiotics have different values of toxicity, which can be life-threatening in high concentrations) and also against environment. In this context, clinicians and researchers seek for efficient alternatives to obtain advanced antimicrobials, such as those of natural origin, or innovative synthetic antibiotics able to reduce the selection of resistant bugs, while avoiding harmful effects both against the host and environment. Nanostructured materials functionalized with natural compounds or synthetic antibiotics proved their potential of being efficient against most clinically relevant microorganisms, including resistant bacteria (superbugs) and biofilm-embedded microbes. Core-shell nanosystems could maximize the amount of bioactive compound functionalized/embedded in the antimicrobial system, to increase its stability, control its release and thus prolong the effect. The aim of this project is to obtain and investigate the antimicrobial and anti-biofilm effect of uniform core shell magnetite nanoparticles containing bioactive molecules includen in/on the obtained shell: plant-derived compounds or antibiotics, against relevant laboratory and clinically isolated bacteria strains.

 

Publications list 2018

ISI papers:

D Ficai, V Grumezescu, O M Fufă, R C Popescu, A M Holban, A Ficai, A M Grumezescu, L Mogoanta, G D Mogosanu and E Andronescu. Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite. Nanomaterials 2018, 8, 633; doi:10.3390/nano8090633.

 

Participation in international conferences:

  1. A M Holban, A M Grumezescu, L M Ditu, C Curutiu, I Gheorghe, V Grumezescu, V Lazar, E Andronescu. Magnetic core-shell nanoparticles with antimicrobial and immunomodulatory effect. Annual International Conference of the RSBMB, 5-7 September 2018, Bucharest, Romania.
  2. A M Holban, A M Grumezescu, G Bianca, M Denisa, H B Mohammed, S Mohsin, M C Chifiriuc, V Lazar, E Andronescu. Core-shell nanoparticles functionalized with essential oils with antimicrobial activity. Joint ESENIAS and DIAS Scientific Conference and 8th ESENIAS Workshop, 26 – 28 September 2018, Bucharest, Romania.
  3. A Holban, L M Ditu, A Grumezescu, C Curutiu, V Lazar, B Vasile, E Andronescu. Impact of inorganic nanoparticles on the virulence of some microbiota isolates with probiotic effect. 6th World Congress on Targeting Microbiota, 28-30 October 2018, Porto, Portugal.