{"id":89,"date":"2020-12-07T16:11:06","date_gmt":"2020-12-07T16:11:06","guid":{"rendered":"http:\/\/alina.amgtranscend.org\/?page_id=89"},"modified":"2022-10-03T04:20:42","modified_gmt":"2022-10-03T04:20:42","slug":"pn-iii-p1-1-1-te-2019-1506","status":"publish","type":"page","link":"https:\/\/alina.amgtranscend.org\/?page_id=89","title":{"rendered":"PN-III-P1-1.1-TE-2019-1506"},"content":{"rendered":"\n

Cod proiect:<\/strong> PN-III-P1-1.1-TE-2019-1506<\/p>\n\n\n\n

Numar contract<\/strong>: 147\/2020<\/p>\n\n\n\n

Perioada de implementare:<\/strong> 01\/11\/2020 – 01\/10\/2022.<\/p>\n\n\n\n

Titlu proiect<\/strong>: Interactiuni in vitro<\/em> intre nanoparticule si tulpini bacteriene cu potential probiotic izolate din microbiota<\/p>\n\n\n\n

Project title<\/strong>: In vitro<\/em> interactions of nanoparticles with human microbiota and probiotic strains<\/p>\n\n\n\n

Acronim<\/strong>: Nano-microbiota
Rezumat (in limba romana)<\/strong>: O mare parte din cercet\u0103rile \u0219tiin\u021bifice recente sus\u021bin ideea c\u0103 terapiile bazate pe modularea microbiotei pot fi utilizate ca metod\u0103 de control a metabolismului gazdei \u0219i \u00een consecin\u021b\u0103, de evitare a  dezvolt\u0103rii multor boli, cum ar fi sindromul metabolic, obezitatea, bolile inflamatorii intestinale, bolile hepatice, bolile infec\u021bioase emergente, diabet, ateroscleroz\u0103, cancer, alergii \u0219i afec\u021biuni ale sistemului nervos central (depresia, anxietatea, boala Parkinson, boala Alzheimer, scleroza multipl\u0103 \u0219i autism). De la produsele alimentare de baza, la utilizarea de produse cosmetice si farmaceutice care pot fi ingerate frecvent, pana la utilizarea de sisteme nanostructurate pentru administrarea \u021bintit\u0103 a unor medicamente, microbiota rezident\u0103 este expusa in permanenta actiunii nanoparticulelor (NPs). Efectul NPs asupra membrilor microbiotei normale (situata in cea mai mare parte la nivel gastro-intestinal) sunt foarte putin cunoscute. Scopul acestui proiect este de a investiga interac\u021biunea in vitro dintre NPs anorganice, intalnite pe scar\u0103 larg\u0103 \u00een practicile medicale comune, \u0219i tulpini bacteriene cultivabile cu potential probiotic izolate din microbiota. Stabilirea impactului unor astfel de nanomateriale, cu privire la propriet\u0103\u021bile antimicrobiene potentiale ale acestora (respectiv inhibarea cre\u0219terii \u0219i multiplic\u0103rii, modularea aderen\u021bei microbiene \u0219i controlul fenomenului de rezisten\u021b\u0103 la antibiotice) asupra microbiotei \u0219i\/sau asupra speciilor cu poten\u021bial probiotic, ar \u00eembun\u0103t\u0103\u021bi semnificativ cuno\u0219tin\u021bele actuale cu privire la modularea echilibrului microbiotei normale in societatea moderna. Deoarece microbiota are capacitatea de a controla numeroase boli moderne, cunoasterea impactului NPs asupra membrilor microbiotei este esentiala pentru instalarea si progresia a numeroase boli (in special a infectiilor).
Abstract (english)<\/strong>: A large amount of recent scientific evidence supports the idea that microbiota-based therapies can be used to modulate host metabolism and the development of numerous diseases, such as metabolic syndrome, obesity, inflammatory bowel disease, liver diseases, emerging infectious diseases, diabetus mellitus, atherosclerosis, cancer, allergies, and central nervous system disorders, including depression, anxiety, Parkinson\u2019s disease, Alzheimer\u2019s disease, multiple sclerosis and symptomologies of autism spectrum disorder.  Such approaches are expected to move from bench to bedside in the near future. From ingested food, to the use of daily products that can be easily ingested, and also to the use of nanosized drug delivery systems for therapy, resident microbiota is prone to be \u201cinfluenced\u201d by these nanomaterials in widely undiscovered ways. The aim of this project is to investigate the in vitro interactions among inorganic nanoparticles (NPs) widely encountered in common practices and cultivable microbiota and probiotic isolates. Establishing the impact of such nanomaterials, in terms of antimicrobial properties, growth inhibition and antipathogenic protection properties (i.e. modulation of the microbial attachment, pathogen growth inhibition, antibiotic resistance control etc) on model microbiota with probiotic potential species would significantly improve the current knowledge regarding microbiota modulation. Since the microbiota has the ability to control the progress of numerous modern diseases, the impact of such nanosized materials in their development and clinical outcome via microbiota modulation (especially infection control) could be significant.<\/p>\n\n\n\n

Echipa proiectului:<\/strong><\/p>\n\n\n\n

Alina Maria Holban <\/strong>– Director<\/p>\n\n\n\n

Lia Mara Ditu <\/strong>– Cercetator<\/p>\n\n\n\n

Alexandru Mihai Grumezescu <\/strong>– Cercetator<\/p>\n\n\n\n

Irina Gheorghe <\/strong>– Cercetator postdoctoral<\/p>\n\n\n\n

Gratiela Gradisteanu <\/strong>– Cercetator postdoctoral<\/p>\n\n\n\n

Ecaterina Sarbu <\/strong>– Doctorand<\/p>\n\n\n\n

Alexandra\u00a0Burdusel\u00a0<\/strong>–\u00a0Doctorand<\/p>\n\n\n\n

Articole ISI:<\/strong><\/p>\n\n\n\n

1. Mohammed, H.B.; Rayyif, S.M.I.; Curutiu, C.; Birca, A.C.; Oprea, O.-C.; Grumezescu, A.M.; Ditu, L.-M.; Gheorghe, I.; Chifiriuc, M.C.; Mihaescu, G.; Holban, A.-M. Eugenol-Functionalized Magnetite Nanoparticles Modulate Virulence and Persistence in Pseudomonas aeruginosa Clinical Strains. Molecules 2021, 26, 2189. https:\/\/doi.org\/10.3390\/molecules26082189<\/a><\/p>\n\n\n\n

2. Gherasim, O.; Popescu, R.C.; Grumezescu, V.; Mogo\u0219anu, G.D.; Mogoant\u0103, L.; Iordache, F.; Holban, A.M.; Vasile, B.\u0218.; B\u00eerc\u0103, A.C.; Oprea, O.-C.; Grumezescu, A.M.; Andronescu, E. MAPLE Coatings Embedded with Essential Oil-Conjugated Magnetite for Anti-Biofilm Applications. Materials 2021, 14, 1612. https:\/\/doi.org\/10.3390\/ma14071612<\/a><\/p>\n\n\n\n

3. Chircov, C.; \u0218tefan, R.-E.; Dolete, G.; Andrei, A.; Holban, A.M.; Oprea, O.-C.; Vasile, B.S.; Neac\u0219u, I.A.; Tih\u0103uan, B. Dextran-Coated Iron Oxide Nanoparticles Loaded with Curcumin for Antimicrobial Therapies. Pharmaceutics 2022, 14, 1057. https:\/\/doi.org\/10.3390\/pharmaceutics14051057<\/a><\/p>\n\n\n\n

4. Lazar V, Holban AM, Curutiu C, Ditu LM. Modulation of Gut Microbiota by Essential Oils and Inorganic Nanoparticles: Impact in Nutrition and Health. Front Nutr. 2022 Jul 8; 9:920413. doi: 10.3389\/fnut.2022.920413.<\/p>\n\n\n\n

Lucrari prezentate la conferinte internationale:<\/strong><\/p>\n\n\n\n

1. A.M. Holban, B.A. Iacob, D. Iordache, A.M. Grumezescu, F. Marinescu, L.M. Ditu, C. Curutiu, V. Lazar. Inorganic nanoparticles modulate antipathogenic effects of microbiota isolates with impact on the infectious process. 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2021, Austria, Viena, 09 \u2013 12. 07. 2021.<\/p>\n\n\n\n

2. A.M. Holban, A. Burdusel, A.M. Grumezescu, L.M. Ditu, C. Curutiu, I. Gheorghe, V. Lazar. Effect of inorganic nanoparticles on probiotic and microbiota isolated bacteria strains. EMRS Spring Meeting, Strasbourg, Franta, 31.05. \u2013 04.06. 2021.<\/p>\n\n\n\n

3. Holban, A.M., Grumezescu, A.M., Capraru, P., Asaftei, M., Ditu, L.M., Curutiu, C., Puscas, N., Lazar, V. Interference of oxide nanoparticles with microbiota isolated Enterococcus sp<\/em> strains. EMRS 2022, Strasbourg, Franta, online, 30.05 \u2013 03.06.2022.<\/p>\n\n\n\n

4. Holban AM, Grumezescu AM, Ditu LM, Curutiu C, Grumezescu V, Van Luc T, Lazar V, Gheorghe I. Inorganic nanoparticles functionalized with Eugenol to Modulate Virulence in Pseudomonas aeruginosa Clinical isolates. 32nd European Congress of Clinical Microbiology & Infectious Diseases; Portugalia, Lisabona, 22. \u2013 27.04.2022.<\/p>\n\n\n\n

5. Holban, A.M., Grumezescu, A.M., Ditu, L.M, Curutiu, C., Lazar, V., Chifiriuc M.C. Inorganic nanoparticles alter growth and antipathogenic effects of probiotic Lactobacillus sp. strains. FEMS 2022; Belgrad, Serbia, 30.06 \u2013 02.07.2022.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cod proiect: PN-III-P1-1.1-TE-2019-1506 Numar contract: 147\/2020 Perioada de implementare: 01\/11\/2020 – 01\/10\/2022. Titlu proiect: Interactiuni in vitro intre nanoparticule si tulpini bacteriene cu potential probiotic izolate din microbiota Project title: In vitro interactions of nanoparticles with human microbiota and probiotic strains Acronim: Nano-microbiotaRezumat (in limba romana): O mare parte din cercet\u0103rile \u0219tiin\u021bifice recente sus\u021bin ideea c\u0103 terapiile bazate pe modularea microbiotei pot fi utilizate ca… Continue reading →<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":42,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=\/wp\/v2\/pages\/89"}],"collection":[{"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=89"}],"version-history":[{"count":3,"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=\/wp\/v2\/pages\/89\/revisions"}],"predecessor-version":[{"id":114,"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=\/wp\/v2\/pages\/89\/revisions\/114"}],"up":[{"embeddable":true,"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=\/wp\/v2\/pages\/42"}],"wp:attachment":[{"href":"https:\/\/alina.amgtranscend.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=89"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}